In Silico Methods for the Discovery of Orthosteric GABAB Receptor Compounds

The GABAB receptor (GABAB-R) is a heterodimeric class C G protein-coupled receptor comprised of the GABAB1a/b and GABAB2 subunits. The endogenous orthosteric agonist γ-amino-butyric acid (GABA) binds within the extracellular Venus flytrap (VFT) domain of the GABAB1a/b subunit. The receptor...

Full description

Bibliographic Details
Main Authors: Linn M. Evenseth, Dawid Warszycki, Andrzej J. Bojarski, Mari Gabrielsen, Ingebrigt Sylte
Format: Article
Language:English
Published: MDPI AG 2019-03-01
Series:Molecules
Subjects:
Online Access:http://www.mdpi.com/1420-3049/24/5/935