In Silico Methods for the Discovery of Orthosteric GABAB Receptor Compounds

In Silico Methods for the Discovery of Orthosteric GABAB Receptor Compounds

The GABAB receptor (GABAB-R) is a heterodimeric class C G protein-coupled receptor comprised of the GABAB1a/b and GABAB2 subunits. The endogenous orthosteric agonist γ-amino-butyric acid (GABA) binds within the extracellular Venus flytrap (VFT) domain of the GABAB1a/b subunit. The receptor...

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Bibliographic Details
Main Authors: Linn M. Evenseth, Dawid Warszycki, Andrzej J. Bojarski, Mari Gabrielsen, Ingebrigt Sylte
Format: Article
Language:English
Published: MDPI AG 2019-03-01
Series:Molecules
Subjects:
GABAB receptor
orthosteric binding site
virtual screening
ligand-based screening
structure-based screening
Online Access:http://www.mdpi.com/1420-3049/24/5/935

Internet

http://www.mdpi.com/1420-3049/24/5/935

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