Early impact of donor CYP3A5 genotype and Graft-to-Recipient Weight Ratio on tacrolimus pharmacokinetics in pediatric liver transplant patients

Early impact of donor CYP3A5 genotype and Graft-to-Recipient Weight Ratio on tacrolimus pharmacokinetics in pediatric liver transplant patients

Abstract Tacrolimus (TAC) pharmacokinetics is influenced by the donor CYP3A5 genotype and the age of pediatric liver recipients. However, an optimization of a genotype-based algorithm for determining TAC starting is needed to earlier achieve stable target levels. As the graft itself is responsible f...

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Bibliographic Details
Main Authors: Michele Pinon, Amedeo De Nicolò, Antonio Pizzol, Miriam Antonucci, Antonio D’Avolio, Loredana Serpe, Dominic Dell’Olio, Silvia Catalano, Francesco Tandoi, Renato Romagnoli, Roberto Canaparo, Pier Luigi Calvo
Format: Article
Language:English
Published: Nature Publishing Group 2021-01-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-020-79574-7

Internet

https://doi.org/10.1038/s41598-020-79574-7

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