Validation of a Single-Nucleotide Polymorphism-Based Non-Invasive Prenatal Test in Twin Gestations: Determination of Zygosity, Individual Fetal Sex, and Fetal Aneuploidy

Validation of a Single-Nucleotide Polymorphism-Based Non-Invasive Prenatal Test in Twin Gestations: Determination of Zygosity, Individual Fetal Sex, and Fetal Aneuploidy

We analyzed maternal plasma cell-free DNA samples from twin pregnancies in a prospective blinded study to validate a single-nucleotide polymorphism (SNP)-based non-invasive prenatal test (NIPT) for zygosity, fetal sex, and aneuploidy. Zygosity was evaluated by looking for either one or two fetal gen...

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Bibliographic Details
Main Authors: Errol R. Norwitz, Gabriel McNeill, Akshita Kalyan, Elizabeth Rivers, Ebad Ahmed, Ling Meng, Phikhanh Vu, Melissa Egbert, Marlene Shapira, Katie Kobara, Sheetal Parmar, Shruti Goel, Sarah A. Prins, Israel Aruh, Nicola Persico, Jared C. Robins, Brian Kirshon, Zachary P. Demko, Allison Ryan, Paul R. Billings, Matthew Rabinowitz, Peter Benn, Kimberly A. Martin, Herman L. Hedriana
Format: Article
Language:English
Published: MDPI AG 2019-06-01
Series:Journal of Clinical Medicine
Subjects:
non-invasive prenatal testing
twins
zygosity
aneuploidy
Down syndrome
prenatal screening
chorionicity
Online Access:https://www.mdpi.com/2077-0383/8/7/937

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https://www.mdpi.com/2077-0383/8/7/937

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