Deglycosylated Azithromycin Targets Transgelin to Enhance Intestinal Smooth Muscle Function

Deglycosylated Azithromycin Targets Transgelin to Enhance Intestinal Smooth Muscle Function

Summary: Azithromycin (AZM) has been widely used as an antibacterial drug for many years. It has also been used to treat delayed gastric emptying. However, it exerts several side effects. We found that deglycosylated AZM (Deg-AZM or CP0119), an AZM metabolite, is a positively strong intestinal agoni...

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Bibliographic Details
Main Authors: Weilong Zhong, Bo Sun, Hao Ruan, Guang Yang, Baoxin Qian, Hailong Cao, Lingfei He, Yunjing Fan, Arthur G. Roberts, Xiang Liu, Xuejiao Hu, Yuan Liang, Qing Ye, Tingting Yin, Bangmao Wang, Cheng Yang, Tao Sun, Honggang Zhou
Format: Article
Language:English
Published: Elsevier 2020-09-01
Series:iScience
Subjects:
Drugs
Medical Biochemistry
Molecular Biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004220306568

Internet

http://www.sciencedirect.com/science/article/pii/S2589004220306568

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