Effect of Mutated <i>ids</i> Overexpression on IDS Enzyme Activity and Developmental Phenotypes in Zebrafish Embryos: A Valuable Index for Assessing Critical Point-Mutations Associated with Mucopolysaccharidosis Type II Occurrence in Humans

Effect of Mutated <i>ids</i> Overexpression on IDS Enzyme Activity and Developmental Phenotypes in Zebrafish Embryos: A Valuable Index for Assessing Critical Point-Mutations Associated with Mucopolysaccharidosis Type II Occurrence in Humans

Mucopolysaccharidosis type II (MPS II) is an X-linked disorder resulting from a deficiency in iduronate 2-sulfatase (IDS), which is reported to be caused by gene mutations in the iduronate 2-sulfatase (IDS) gene. Many IDS mutation sites have not yet had their causal relationship with MPS II characte...

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Bibliographic Details
Main Authors: Cheng-Yung Lin, Hsiang-Yu Lin, Chih-Kuang Chuang, Po-Hsiang Zhang, Ru-Yi Tu, Shuan-Pei Lin, Huai-Jen Tsai
Format: Article
Language:English
Published: MDPI AG 2020-10-01
Series:Diagnostics
Subjects:
enzyme activity
IDS
mucopolysaccharidosis type II
overexpression
phenotype
zebrafish
Online Access:https://www.mdpi.com/2075-4418/10/10/854

Internet

https://www.mdpi.com/2075-4418/10/10/854

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