Ambient oxygen promotes tumorigenesis.

Oxygen serves as an essential factor for oxidative stress, and it has been shown to be a mutagen in bacteria. While it is well established that ambient oxygen can also cause genomic instability in cultured mammalian cells, its effect on de novo tumorigenesis at the organismal level is unclear. Herei...

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Bibliographic Details
Main Authors: Ho Joong Sung, Wenzhe Ma, Matthew F Starost, Cory U Lago, Philip K Lim, Michael N Sack, Ju-Gyeong Kang, Ping-yuan Wang, Paul M Hwang
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-05-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21589870/?tool=EBI