Antitumor effects of a sirtuin inhibitor, tenovin-6, against gastric cancer cells via death receptor 5 up-regulation.

Antitumor effects of a sirtuin inhibitor, tenovin-6, against gastric cancer cells via death receptor 5 up-regulation.

Up-regulated sirtuin 1 (SIRT1), an NAD+-dependent class III histone deacetylase, deacetylates p53 and inhibits its transcriptional activity, leading to cell survival. SIRT1 overexpression has been reported to predict poor survival in some malignancies, including gastric cancer. However, the antitumo...

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Bibliographic Details
Main Authors: Sachiko Hirai, Shinji Endo, Rie Saito, Mitsuaki Hirose, Takunori Ueno, Hideo Suzuki, Kenji Yamato, Masato Abei, Ichinosuke Hyodo
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4102575?pdf=render

Internet

http://europepmc.org/articles/PMC4102575?pdf=render

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