Construction and evaluation of an efficient C‐Jun siRNA to downregulate matrix metalloproteinase in human keratinocytes and fibroblasts under UV exposure

Construction and evaluation of an efficient C‐Jun siRNA to downregulate matrix metalloproteinase in human keratinocytes and fibroblasts under UV exposure

Abstract Background C‐Jun and EGFR have not been explored as targets via the mechanism of RNA silencing. Hence, this study designed an efficient C‐Jun‐h‐825 small interfering RNA (siRNA) and investigated its effect on matrix metalloproteinase (MMP) and collagen expression in human keratinocytes expo...

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Bibliographic Details
Main Authors: Hong Xiao, Ruinian Yang, Fang Yang, Yanan Zhao, Yin Liu
Format: Article
Language:English
Published: Wiley 2020-01-01
Series:Molecular Genetics & Genomic Medicine
Subjects:
C‐Jun
collagen
matrix metalloproteinase
photoaging
siRNA
ultraviolet radiation
Online Access:https://doi.org/10.1002/mgg3.1047

Internet

https://doi.org/10.1002/mgg3.1047

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