Dentate gyrus network dysfunctions precede the symptomatic phase in a genetic mouse model of seizures

Dentate gyrus network dysfunctions precede the symptomatic phase in a genetic mouse model of seizures

Neuronal circuit disturbances that lead to hyperexcitability in the cortico-hippocampal network are one of the landmarks of temporal lobe epilepsy. The dentate gyrus (DG) network plays an important role in regulating the excitability of the entire hippocampus by filtering and integrating information...

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Bibliographic Details
Main Authors: Oana eToader, Nicola eForte, Marta eOrlando, Enrico eFerrea, Andrea eRaimondi, Pietro eBaldelli, Fabio eBenfenati, Lucian eMedrihan
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-08-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Dentate Gyrus
Epilepsy
Synapsins
mossy cells
excitatory inhibitory balance
Online Access:http://journal.frontiersin.org/Journal/10.3389/fncel.2013.00138/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fncel.2013.00138/full

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