A Switch from Cell-Associated to Soluble PDGF-B Protects against Atherosclerosis, despite Driving Extramedullary Hematopoiesis

A Switch from Cell-Associated to Soluble PDGF-B Protects against Atherosclerosis, despite Driving Extramedullary Hematopoiesis

Platelet-derived growth factor B (PDGF-B) is a mitogenic, migratory and survival factor. Cell-associated PDGF-B recruits stabilizing pericytes towards blood vessels through retention in extracellular matrix. We hypothesized that the genetic ablation of cell-associated PDGF-B by retention motif delet...

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Bibliographic Details
Main Authors: Renée J. H. A. Tillie, Thomas L. Theelen, Kim van Kuijk, Lieve Temmerman, Jenny de Bruijn, Marion Gijbels, Christer Betsholtz, Erik A. L. Biessen, Judith C. Sluimer
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:Cells
Subjects:
PDGF-B
atherosclerosis
plaque stability
fibrosis
hematopoiesis
Online Access:https://www.mdpi.com/2073-4409/10/7/1746

Internet

https://www.mdpi.com/2073-4409/10/7/1746

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