Extreme heterogeneity of influenza virus infection in single cells

Viral infection can dramatically alter a cell’s transcriptome. However, these changes have mostly been studied by bulk measurements on many cells. Here we use single-cell mRNA sequencing to examine the transcriptional consequences of influenza virus infection. We find extremely wide cell-to-cell var...

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Bibliographic Details
Main Authors: Alistair B Russell, Cole Trapnell, Jesse D Bloom
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2018-02-01
Series:eLife
Subjects:
Online Access:https://elifesciences.org/articles/32303