LRRK2 Kinase Activity and Biology are Not Uniformly Predicted by its Autophosphorylation and Cellular Phosphorylation Site Status

LRRK2 Kinase Activity and Biology are Not Uniformly Predicted by its Autophosphorylation and Cellular Phosphorylation Site Status

Missense mutations in the Leucine Rich Repeat protein Kinase 2 (LRRK2) gene are the most common genetic predisposition to develop Parkinson’s disease (PD) LRRK2 is a large multi-domain phosphoprotein with a GTPase domain and a serine/threonine protein kinase domain whose activity is implicated in ne...

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Bibliographic Details
Main Authors: April eReynolds, Elizabeth A Doggett, Steven M. Riddle, Connie S Lebakken, R. Jeremy eNichols
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-06-01
Series:Frontiers in Molecular Neuroscience
Subjects:
Phosphorylation
Parkinson’s disease
kinase
GTPase
kinase inhibitor
LRRK2
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnmol.2014.00054/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fnmol.2014.00054/full

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