Uses of Next-Generation Sequencing Technologies for the Diagnosis of Primary Immunodeficiencies

Uses of Next-Generation Sequencing Technologies for the Diagnosis of Primary Immunodeficiencies

Primary immunodeficiencies (PIDs) are genetic disorders impairing host immunity, leading to life-threatening infections, autoimmunity, and/or malignancies. Genomic technologies have been critical for expediting the discovery of novel genetic defects underlying PIDs, expanding our knowledge of the co...

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Bibliographic Details
Main Authors: Michael Seleman, Rodrigo Hoyos-Bachiloglu, Raif S. Geha, Janet Chou
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-07-01
Series:Frontiers in Immunology
Subjects:
primary immunodeficiency
next-generation sequencing
whole exome sequencing
gene panels
genomics
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.00847/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2017.00847/full

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