Methylphenidate attenuates limbic brain inhibition after cocaine-cues exposure in cocaine abusers.

Methylphenidate attenuates limbic brain inhibition after cocaine-cues exposure in cocaine abusers.

Dopamine (phasic release) is implicated in conditioned responses. Imaging studies in cocaine abusers show decreases in striatal dopamine levels, which we hypothesize may enhance conditioned responses since tonic dopamine levels modulate phasic dopamine release. To test this we assessed the effects o...

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Bibliographic Details
Main Authors: Nora D Volkow, Gene-Jack Wang, Dardo Tomasi, Frank Telang, Joanna S Fowler, Kith Pradhan, Millard Jayne, Jean Logan, Rita Z Goldstein, Nelly Alia-Klein, Christopher Wong
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-07-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2901385?pdf=render

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http://europepmc.org/articles/PMC2901385?pdf=render

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