Impact of Tranexamic Acid on Chondrocytes and Osteogenically Differentiated Human Mesenchymal Stromal Cells (hMSCs) In Vitro

Impact of Tranexamic Acid on Chondrocytes and Osteogenically Differentiated Human Mesenchymal Stromal Cells (hMSCs) In Vitro

The topical application of tranexamic acid (TXA) helps to prevent post-operative blood loss in total joint replacements. Despite these findings, the effects on articular and periarticular tissues remain unclear. Therefore, this in vitro study examined the effects of varying exposure times and concen...

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Bibliographic Details
Main Authors: Mike Wagenbrenner, Tizian Heinz, Konstantin Horas, Axel Jakuscheit, Joerg Arnholdt, Susanne Mayer-Wagner, Maximilian Rudert, Boris M. Holzapfel, Manuel Weißenberger
Format: Article
Language:English
Published: MDPI AG 2020-11-01
Series:Journal of Clinical Medicine
Subjects:
tranexamic acid
hMSCs
chondrocytes
osteoarthritis
toxicity
differentiation capacity
Online Access:https://www.mdpi.com/2077-0383/9/12/3880

Internet

https://www.mdpi.com/2077-0383/9/12/3880

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