P53-R273H mutation enhances colorectal cancer stemness through regulating specific lncRNAs

P53-R273H mutation enhances colorectal cancer stemness through regulating specific lncRNAs

Abstract Background TP53 is one of the most frequently mutated genes among all cancer types, and TP53 mutants occur more than 60% in colorectal cancer (CRC). Among all mutants, there are three hot spots, including p53-R175H, p53-R248W and p53-R273H. Emerging evidence attributes cancer carcinogenesis...

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Bibliographic Details
Main Authors: Yuechao Zhao, Yiran Li, Jie Sheng, Fan Wu, Kai Li, Rong Huang, Xiaojuan Wang, Tao Jiao, Xin Guan, Yan Lu, Xiao Chen, Zhiwen Luo, Yanchi Zhou, Hanjie Hu, Wenjie Liu, Boyu Du, Shiying Miao, Jianqiang Cai, Linfang Wang, Hong Zhao, Jianming Ying, Xinyu Bi, Wei Song
Format: Article
Language:English
Published: BMC 2019-08-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
p53
lncRNAs
Colorectal cancer
Cancer stem cell
Online Access:http://link.springer.com/article/10.1186/s13046-019-1375-9

Internet

http://link.springer.com/article/10.1186/s13046-019-1375-9

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