Dexamethasone induces osteoblast apoptosis through ROS-PI3K/AKT/GSK3β signaling pathway

Dexamethasone induces osteoblast apoptosis through ROS-PI3K/AKT/GSK3β signaling pathway

Background: Osteoblasts play important roles in the process of osteogenesis and prevention of osteonecrosis. Dexamethasone (Dex), a type of glucocorticoids (GCs), induces apoptosis of osteoblasts and leads to the occurrence of non-traumatic osteonecrosis. This study aimed to explore the effects of p...

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Bibliographic Details
Main Authors: Shuang Deng, Guo Dai, Sen Chen, Zhigang Nie, Jianlin Zhou, Hongsong Fang, Hao Peng
Format: Article
Language:English
Published: Elsevier 2019-02-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Osteonecrosis
Osteoblasts apoptosis
Dexamethasone
Reactive oxygen species
Phosphatidylinositol 3-kinase/protein kinase 3
Glycogen synthase kinase 3β
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332218336916

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http://www.sciencedirect.com/science/article/pii/S0753332218336916

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