TNF-α-induced alterations in stromal progenitors enhance leukemic stem cell growth via CXCR2 signaling

TNF-α-induced alterations in stromal progenitors enhance leukemic stem cell growth via CXCR2 signaling

Summary: Chronic myeloid leukemia (CML) is propagated by leukemia stem cells (LSCs) that are not eradicated by tyrosine kinase inhibitor (TKI) treatment and persist as a source of disease recurrence. Bone marrow (BM) mesenchymal niches play an essential role in hematopoietic stem cell (HSC) and LSC...

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Bibliographic Details
Main Authors: Puneet Agarwal, Hui Li, Kwangmin Choi, Kathleen Hueneman, Jianbo He, Robert S. Welner, Daniel T. Starczynowski, Ravi Bhatia
Format: Article
Language:English
Published: Elsevier 2021-07-01
Series:Cell Reports
Subjects:
6C3
CXCL1
CXCR2
CML
inflammation
leukemic stem cells
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124721007841

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http://www.sciencedirect.com/science/article/pii/S2211124721007841

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