Novel Clostridium difficile Anti-Toxin (TcdA and TcdB) Humanized Monoclonal Antibodies Demonstrate In Vitro Neutralization across a Broad Spectrum of Clinical Strains and In Vivo Potency in a Hamster Spore Challenge Model.

Novel Clostridium difficile Anti-Toxin (TcdA and TcdB) Humanized Monoclonal Antibodies Demonstrate In Vitro Neutralization across a Broad Spectrum of Clinical Strains and In Vivo Potency in a Hamster Spore Challenge Model.

Clostridium difficile (C. difficile) infection (CDI) is the main cause of nosocomial antibiotic-associated colitis and increased incidence of community-associated diarrhea in industrialized countries. At present, the primary treatment of CDI is antibiotic administration, which is effective but often...

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Bibliographic Details
Main Authors: Hongyu Qiu, Robyn Cassan, Darrell Johnstone, Xiaobing Han, Antony George Joyee, Monica McQuoid, Andrea Masi, John Merluza, Bryce Hrehorak, Ross Reid, Kieron Kennedy, Bonnie Tighe, Carla Rak, Melanie Leonhardt, Brian Dupas, Laura Saward, Jody D Berry, Cory L Nykiforuk
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4919053?pdf=render

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http://europepmc.org/articles/PMC4919053?pdf=render

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