Crosstalk between Smad and Mitogen-Activated Protein Kinases for the Regulation of Apoptosis in Cyclosporine A- Induced Renal Tubular Injury

Crosstalk between Smad and Mitogen-Activated Protein Kinases for the Regulation of Apoptosis in Cyclosporine A- Induced Renal Tubular Injury

Background/Aims: It remains elusive whether there is a crosstalk between Smad and mitogen-activated protein kinases (MAPKs) and whether it regulates cyclosporine A (CyA)-induced apoptosis in renal proximal tubular cells (RPTCs). Methods: The effect of CyA on nuclear translocation of Smad2/3 and MAPK...

Full description

Bibliographic Details
Main Authors: Hideyuki Iwayama, Tatsuo Sakamoto, Akihiro Nawa, Norishi Ueda
Format: Article
Language:English
Published: Karger Publishers 2011-10-01
Series:Nephron Extra
Subjects:
Smad
Apoptosis
Cyclosporine nephrotoxicity
Epidermal growth factor
Mitogen-activated protein kinases
Online Access:http://www.karger.com/Article/FullText/333014

Internet

http://www.karger.com/Article/FullText/333014

Similar Items