Ketamine-induced neurotoxicity in neurodevelopment: A synopsis of main pathways based on recent in vivo experimental findings

Ketamine-induced neurotoxicity in neurodevelopment: A synopsis of main pathways based on recent in vivo experimental findings

Ketamine, a phencyclidine derivative and N-methyl-D-aspartate (NMDA) receptor antagonist, is widely used as an anesthetic, analgesic, and sedative agent in daily pediatric practice. Experimental studies have suggested that early prenatal or postnatal exposure to ketamine can induce neuroapoptosis, a...

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Bibliographic Details
Main Authors: Konstantina Kalopita, Athanasios Armakolas, Anastassios Philippou, Apostolos Zarros, Panagoula Angelogianni
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2021-01-01
Series:Journal of Anaesthesiology Clinical Pharmacology
Subjects:
ketamine
neurodevelopment
neurogenesis
nmda receptors
oxidative stress
Online Access:http://www.joacp.org/article.asp?issn=0970-9185;year=2021;volume=37;issue=1;spage=37;epage=42;aulast=Kalopita

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http://www.joacp.org/article.asp?issn=0970-9185;year=2021;volume=37;issue=1;spage=37;epage=42;aulast=Kalopita

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