Identification of EP300 as a Key Gene Involved in Antipsychotic-Induced Metabolic Dysregulation Based on Integrative Bioinformatics Analysis of Multi-Tissue Gene Expression Data

Identification of EP300 as a Key Gene Involved in Antipsychotic-Induced Metabolic Dysregulation Based on Integrative Bioinformatics Analysis of Multi-Tissue Gene Expression Data

Antipsychotics (APs) are associated with weight gain and other metabolic abnormalities such as hyperglycemia, dyslipidemia and metabolic syndrome. This translational study aimed to uncover the underlying molecular mechanisms and identify the key genes involved in AP-induced metabolic effects. An int...

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Bibliographic Details
Main Authors: Albert Martínez-Pinteño, Patricia Gassó, Llucia Prohens, Alex G. Segura, Mara Parellada, Jerónimo Saiz-Ruiz, Manuel J. Cuesta, Miguel Bernardo, Amalia Lafuente, Sergi Mas, Natalia Rodríguez
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Pharmacology
Subjects:
antipsychotics
weight gain
metabolic syndrome
pharmacogenetics
EP300
gene
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.729474/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2021.729474/full

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