Identification and characterization of inhibitors of human apurinic/apyrimidinic endonuclease APE1.

Identification and characterization of inhibitors of human apurinic/apyrimidinic endonuclease APE1.

APE1 is the major nuclease for excising abasic (AP) sites and particular 3'-obstructive termini from DNA, and is an integral participant in the base excision repair (BER) pathway. BER capacity plays a prominent role in dictating responsiveness to agents that generate oxidative or alkylation DNA...

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Bibliographic Details
Main Authors: Anton Simeonov, Avanti Kulkarni, Dorjbal Dorjsuren, Ajit Jadhav, Min Shen, Daniel R McNeill, Christopher P Austin, David M Wilson
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-06-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2685009?pdf=render

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http://europepmc.org/articles/PMC2685009?pdf=render

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