CuZn-Superoxide Dismutase in D90A Heterozygotes from Recessive and Dominant ALS Pedigrees

CuZn-Superoxide Dismutase in D90A Heterozygotes from Recessive and Dominant ALS Pedigrees

Mutations in CuZn-superoxide dismutase (CuZn-SOD) have been linked to ALS. In most cases ALS is inherited as a dominant trait and there is marked reduction in CuZn-SOD activity in samples from the patients. The D90A mutation, however, mostly causes ALS as a recessive trait and shows near normal CuZn...

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Bibliographic Details
Main Authors: P.Andreas Jonsson, Åsa Bäckstrand, Peter M. Andersen, Johan Jacobsson, Matthew Parton, Chris Shaw, Robert Swingler, Pamela J. Shaw, Wim Robberecht, Albert C. Ludolph, Teepu Siddique, Veronica I. Skvortsova, Stefan L. Marklund
Format: Article
Language:English
Published: Elsevier 2002-08-01
Series:Neurobiology of Disease
Subjects:
oxygen radicals
amyotrophic lateral sclerosis
erythrocytes
superoxide dismutase
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996102905085

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http://www.sciencedirect.com/science/article/pii/S0969996102905085

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