Disruption of the C-terminal helix by single amino acid deletion is directly responsible for impaired cholesterol efflux ability of apolipoprotein A-I Nichinan

Disruption of the C-terminal helix by single amino acid deletion is directly responsible for impaired cholesterol efflux ability of apolipoprotein A-I Nichinan

Apolipoprotein A-I (apoA-I) Nichinan, a naturally occurring variant with ΔE235 in the C terminus, is associated with low plasma HDL levels. Here, we investigated the tertiary structure, lipid-binding properties, and ability to induce cellular cholesterol efflux of apoA-I Nichinan and its C-terminal...

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Bibliographic Details
Main Authors: Momoe Kono, Toshitaka Tanaka, Masafumi Tanaka, Charulatha Vedhachalam, Palaniappan S. Chetty, David Nguyen, Padmaja Dhanasekaran, Sissel Lund-Katz, Michael C. Phillips, Hiroyuki Saito
Format: Article
Language:English
Published: Elsevier 2010-04-01
Series:Journal of Lipid Research
Subjects:
natural mutation
high density lipoprotein
tertiary structure
lipid binding
peptide
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520304909

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http://www.sciencedirect.com/science/article/pii/S0022227520304909

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