Dominant drug targets suppress the emergence of antiviral resistance

Dominant drug targets suppress the emergence of antiviral resistance

The emergence of drug resistance can defeat the successful treatment of pathogens that display high mutation rates, as exemplified by RNA viruses. Here we detail a new paradigm in which a single compound directed against a ‘dominant drug target’ suppresses the emergence of naturally occurring drug-r...

Full description

Bibliographic Details
Main Authors: Elizabeth J Tanner, Hong-mei Liu, M Steven Oberste, Mark Pallansch, Marc S Collett, Karla Kirkegaard
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2014-11-01
Series:eLife
Subjects:
genetic dominance
drug resistance
virus evolution
quasispecies
oligomeric protein
Online Access:https://elifesciences.org/articles/03830

Internet

https://elifesciences.org/articles/03830

Similar Items