Dominant drug targets suppress the emergence of antiviral resistance
The emergence of drug resistance can defeat the successful treatment of pathogens that display high mutation rates, as exemplified by RNA viruses. Here we detail a new paradigm in which a single compound directed against a ‘dominant drug target’ suppresses the emergence of naturally occurring drug-r...
Main Authors: | Elizabeth J Tanner, Hong-mei Liu, M Steven Oberste, Mark Pallansch, Marc S Collett, Karla Kirkegaard |
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Format: | Article |
Language: | English |
Published: |
eLife Sciences Publications Ltd
2014-11-01
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Series: | eLife |
Subjects: | |
Online Access: | https://elifesciences.org/articles/03830 |
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