Spray-Dried Amorphous Solid Dispersions of Griseofulvin in HPC/Soluplus/SDS: Elucidating the Multifaceted Impact of SDS as a Minor Component

Spray-Dried Amorphous Solid Dispersions of Griseofulvin in HPC/Soluplus/SDS: Elucidating the Multifaceted Impact of SDS as a Minor Component

This study aimed to elucidate the impact of a common anionic surfactant, sodium dodecyl sulfate (SDS), along with hydroxypropyl cellulose (HPC) and Soluplus (Sol) on the release of griseofulvin (GF), a poorly soluble drug, from amorphous solid dispersions (ASDs). Solutions of 2.5% GF and 2.5%&#8...

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Bibliographic Details
Main Authors: Mahbubur Rahman, Stephanie Ahmad, James Tarabokija, Nathaniel Parker, Ecevit Bilgili
Format: Article
Language:English
Published: MDPI AG 2020-02-01
Series:Pharmaceutics
Subjects:
amorphous solid dispersions
spray drying
wettability
supersaturation
recrystallization
drug release
Online Access:https://www.mdpi.com/1999-4923/12/3/197

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https://www.mdpi.com/1999-4923/12/3/197

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