Augmenting Vacuolar H<sup>+</sup>-ATPase Function Prevents Cardiomyocytes from Lipid-Overload Induced Dysfunction

Augmenting Vacuolar H<sup>+</sup>-ATPase Function Prevents Cardiomyocytes from Lipid-Overload Induced Dysfunction

The diabetic heart is characterized by a shift in substrate utilization from glucose to lipids, which may ultimately lead to contractile dysfunction. This substrate shift is facilitated by increased translocation of lipid transporter CD36 (SR-B2) from endosomes to the sarcolemma resulting in increas...

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Bibliographic Details
Main Authors: Shujin Wang, Li-Yen Wong, Dietbert Neumann, Yilin Liu, Aomin Sun, Gudrun Antoons, Agnieszka Strzelecka, Jan F.C. Glatz, Miranda Nabben, Joost J.F.P. Luiken
Format: Article
Language:English
Published: MDPI AG 2020-02-01
Series:International Journal of Molecular Sciences
Subjects:
vacuolar h<sup>+</sup>-atpase
lipid accumulation
insulin resistance
contractile function
diabetic heart
Online Access:https://www.mdpi.com/1422-0067/21/4/1520

Internet

https://www.mdpi.com/1422-0067/21/4/1520

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