The Ethnic-Specific Spectrum of Germline Nucleotide Variants in DNA Damage Response and Repair Genes in Hereditary Breast and Ovarian Cancer Patients of Tatar Descent

The Ethnic-Specific Spectrum of Germline Nucleotide Variants in DNA Damage Response and Repair Genes in Hereditary Breast and Ovarian Cancer Patients of Tatar Descent

The Russian population consists of more than 100 ethnic groups, presenting a unique opportunity for the identification of hereditary pathogenic mutations. To gain insight into the landscape of heredity pathogenic variants, we employed targeted next-generation sequencing to analyze the germline mutat...

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Bibliographic Details
Main Authors: Olga I. Brovkina, Leila Shigapova, Daria A. Chudakova, Marat G. Gordiev, Rafael F. Enikeev, Maxim O. Druzhkov, Dmitriy S. Khodyrev, Elena I. Shagimardanova, Alexey G. Nikitin, Oleg A. Gusev
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-10-01
Series:Frontiers in Oncology
Subjects:
breast cancer
BRCA1
BRCA2
CDK12
homologous recombination repair
next-generation sequencing
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2018.00421/full

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https://www.frontiersin.org/article/10.3389/fonc.2018.00421/full

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