Methemoglobin Is an Endogenous Toll-Like Receptor 4 Ligand—Relevance to Subarachnoid Hemorrhage

Methemoglobin Is an Endogenous Toll-Like Receptor 4 Ligand—Relevance to Subarachnoid Hemorrhage

Neuroinflammation is a well-recognized consequence of subarachnoid hemorrhage (SAH), and may be responsible for important complications of SAH. Signaling by Toll-like receptor 4 (TLR4)-mediated nuclear factor κB (NFκB) in microglia plays a critical role in neuronal damage after SAH. Three molecules...

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Bibliographic Details
Main Authors: Min Seong Kwon, Seung Kyoon Woo, David B. Kurland, Sung Hwan Yoon, Andre F. Palmer, Uddyalok Banerjee, Sana Iqbal, Svetlana Ivanova, Volodymyr Gerzanich, J. Marc Simard
Format: Article
Language:English
Published: MDPI AG 2015-03-01
Series:International Journal of Molecular Sciences
Subjects:
subarachnoid hemorrhage
methemoglobin
hemoglobin
Toll-like receptor 4
tumor necrosis factor α
neuroinflammation
Online Access:http://www.mdpi.com/1422-0067/16/3/5028

Internet

http://www.mdpi.com/1422-0067/16/3/5028

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