Maternally Inherited Differences within Mitochondrial Complex I Control Murine Healthspan

Maternally Inherited Differences within Mitochondrial Complex I Control Murine Healthspan

Mitochondrial complex I—the largest enzyme complex of the mitochondrial oxidative phosphorylation machinery—has been proposed to contribute to a variety of age-related pathological alterations as well as longevity. The enzyme complex-consisting proteins are encoded by both nuclea...

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Bibliographic Details
Main Authors: Misa Hirose, Paul Schilf, Kim Zarse, Hauke Busch, Georg Fuellen, Olaf Jöhren, Rüdiger Köhling, Inke R. König, Barbara Richer, Jan Rupp, Markus Schwaninger, Karsten Seeger, Christian Sina, Michael Ristow, Saleh M. Ibrahim
Format: Article
Language:English
Published: MDPI AG 2019-07-01
Series:Genes
Subjects:
Conplastic mouse strains
mitochondrially encoded complex I
mitochondrial DNA (mtDNA)
lifespan
<i>mt-Nd2</i>
healthspan
glucose metabolism
mice
Online Access:https://www.mdpi.com/2073-4425/10/7/532

Internet

https://www.mdpi.com/2073-4425/10/7/532

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