Infiltration by CXCL10 Secreting Macrophages Is Associated With Antitumor Immunity and Response to Therapy in Ovarian Cancer Subtypes

Infiltration by CXCL10 Secreting Macrophages Is Associated With Antitumor Immunity and Response to Therapy in Ovarian Cancer Subtypes

Ovarian carcinomas (OCs) are poorly immunogenic and immune checkpoint inhibitors (ICIs) have offered a modest benefit. In this study, high CD3+ T-cells and CD163+ tumor-associated macrophages (TAMs) densities identify a subgroup of immune infiltrated high-grade serous carcinomas (HGSCs) with better...

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Bibliographic Details
Main Authors: Laura Ardighieri, Francesco Missale, Mattia Bugatti, Luisa Benerini Gatta, Irene Pezzali, Matilde Monti, Stefano Gottardi, Laura Zanotti, Eliana Bignotti, Antonella Ravaggi, Germana Tognon, Franco Odicino, Stefano Calza, Yoann Missolo-Koussou, Carola Hermine Ries, Julie Helft, William Vermi
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Immunology
Subjects:
ovarian cancer
macrophage
signature
CXCL10
polarization
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.690201/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.690201/full

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