ERK1/2 communicates GPCR and EGFR signaling pathways to promote CTGF-mediated hypertrophic cardiomyopathy upon Ang-II stimulation

ERK1/2 communicates GPCR and EGFR signaling pathways to promote CTGF-mediated hypertrophic cardiomyopathy upon Ang-II stimulation

Abstract Background Hypertrophic cardiomyopathy occurs along with pathological phenomena such as cardiac hypertrophy, myocardial fibrosis and cardiomyocyte activity. However, few of the specific molecular mechanisms underlying this pathological condition have been mentioned. Methods All target prote...

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Bibliographic Details
Main Authors: Xin Liu, Lin Lin, Qing Li, Yajuan Ni, Chaoying Zhang, Shuguang Qin, Jin Wei
Format: Article
Language:English
Published: BMC 2019-06-01
Series:BMC Molecular and Cell Biology
Subjects:
ERK1/2
CTGF
EGFR
Hypertrophic cardiomyopathy
Online Access:http://link.springer.com/article/10.1186/s12860-019-0202-7

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http://link.springer.com/article/10.1186/s12860-019-0202-7

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