Identification of novel LEPR mutations in Pakistani families with morbid childhood obesity

Identification of novel LEPR mutations in Pakistani families with morbid childhood obesity

Abstract Background Mutations in the genes encoding leptin (LEP), the leptin receptor (LEPR), and the melanocortin 4 receptor (MC4R) are known to cause severe early-onset childhood obesity. The aim of the current study was to examine the prevalence of damaging LEP, LEPR, and MC4R mutations in Pakist...

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Bibliographic Details
Main Authors: Robina Khan Niazi, Anette P Gjesing, Mette Hollensted, Christian Theil Have, Niels Grarup, Oluf Pedersen, Asmat Ullah, Gulbin Shahid, Wasim Ahmad, Asma Gul, Torben Hansen
Format: Article
Language:English
Published: BMC 2018-11-01
Series:BMC Medical Genetics
Subjects:
Early-onset obesity
Hyperphagia
Leptin
Leptin receptor
Melanocortin 4 receptor
Monogenic obesity
Online Access:http://link.springer.com/article/10.1186/s12881-018-0710-x

Internet

http://link.springer.com/article/10.1186/s12881-018-0710-x

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