Depleting RhoA/Stress Fiber-Organized Fibronectin Matrices on Tumor Cells Non-Autonomously Aggravates Fibroblast-Driven Tumor Cell Growth

Depleting RhoA/Stress Fiber-Organized Fibronectin Matrices on Tumor Cells Non-Autonomously Aggravates Fibroblast-Driven Tumor Cell Growth

Fibronectin (FN) expressed by tumor cells has been known to be tumor suppressive but the pericellular FN (periFN) assembled on circulating tumor cells appears to evidently promote distant metastasis. Whereas the regulation of periFN assembly in suspended cells has currently been under investigation,...

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Bibliographic Details
Main Authors: Li-Tzu Huang, Chen-Lung Tsai, Shin-Huei Huang, Ming-Min Chang, Wen-Tsan Chang, Li-Hsin Cheng, Hung-Chi Cheng
Format: Article
Language:English
Published: MDPI AG 2020-11-01
Series:International Journal of Molecular Sciences
Subjects:
Fibronectin (FN)
pericellular FN matrices
actin stress fiber cytoskeleton
RhoA
tumor microenvironments
cancer associated fibroblasts
Online Access:https://www.mdpi.com/1422-0067/21/21/8272

Internet

https://www.mdpi.com/1422-0067/21/21/8272

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