Ligand binding and conformational changes of SUR1 subunit in pancreatic ATP-sensitive potassium channels

Ligand binding and conformational changes of SUR1 subunit in pancreatic ATP-sensitive potassium channels

Abstract ATP-sensitive potassium channels (KATP) are energy sensors on the plasma membrane. By sensing the intracellular ADP/ATP ratio of β-cells, pancreatic KATP channels control insulin release and regulate metabolism at the whole body level. They are implicated in many metabolic disorders and dis...

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Bibliographic Details
Main Authors: Jing-Xiang Wu, Dian Ding, Mengmeng Wang, Yunlu Kang, Xin Zeng, Lei Chen
Format: Article
Language:English
Published: SpringerOpen 2018-03-01
Series:Protein & Cell
Subjects:
KATP
SUR
ABC transporter
glibenclamide
sulfonylurea
diabetes
Online Access:http://link.springer.com/article/10.1007/s13238-018-0530-y

Internet

http://link.springer.com/article/10.1007/s13238-018-0530-y

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