Paternal Age Explains a Major Portion of De Novo Germline Mutation Rate Variability in Healthy Individuals.

Paternal Age Explains a Major Portion of De Novo Germline Mutation Rate Variability in Healthy Individuals.

De novo mutations (DNM) are an important source of rare variants and are increasingly being linked to the development of many diseases. Recently, the paternal age effect has been the focus of a number of studies that attempt to explain the observation that increasing paternal age increases the risk...

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Bibliographic Details
Main Authors: Simon L Girard, Cynthia V Bourassa, Louis-Philippe Lemieux Perreault, Marc-André Legault, Amina Barhdadi, Amirthagowri Ambalavanan, Mara Brendgen, Frank Vitaro, Anne Noreau, Ginette Dionne, Richard E Tremblay, Patrick A Dion, Michel Boivin, Marie-Pierre Dubé, Guy A Rouleau
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5056704?pdf=render

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http://europepmc.org/articles/PMC5056704?pdf=render

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