Genomic profile of MYCN non-amplified neuroblastoma and potential for immunotherapeutic strategies in neuroblastoma

Genomic profile of MYCN non-amplified neuroblastoma and potential for immunotherapeutic strategies in neuroblastoma

Abstract Background MYCN amplification is the most important genomic feature in neuroblastoma (NB). However, limited studies have been conducted on the MYCN non-amplified NB including low- and intermediate-risk NB. Here, the genomic characteristics of MYCN non-amplified NB were studied to allow for...

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Bibliographic Details
Main Authors: Eunjin Lee, Ji Won Lee, Boram Lee, Kyunghee Park, Joonho Shim, Keon Hee Yoo, Hong Hoe Koo, Ki Woong Sung, Woong-Yang Park
Format: Article
Language:English
Published: BMC 2020-11-01
Series:BMC Medical Genomics
Subjects:
MYCN non-amplified neuroblastoma
Tumour mutation burden
Mutational signature
Genomic profile
Immunotherapy
Online Access:http://link.springer.com/article/10.1186/s12920-020-00819-5

Internet

http://link.springer.com/article/10.1186/s12920-020-00819-5

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