Cilostazol, a Phosphodiesterase 3 Inhibitor, Moderately Attenuates Behaviors Depending on Sex in the Ts65Dn Mouse Model of Down Syndrome

Cilostazol, a Phosphodiesterase 3 Inhibitor, Moderately Attenuates Behaviors Depending on Sex in the Ts65Dn Mouse Model of Down Syndrome

People with Down syndrome, which is a trisomy of chromosome 21, exhibit intellectual disability from infancy and neuropathology similar to Alzheimer’s disease, such as amyloid plaques, from an early age. Recently, we showed that cilostazol, a selective inhibitor of phosphodiesterase (PDE) 3, promote...

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Bibliographic Details
Main Authors: Masahiro Tsuji, Makiko Ohshima, Yumi Yamamoto, Satoshi Saito, Yorito Hattori, Emi Tanaka, Akihiko Taguchi, Masafumi Ihara, Yuko Ogawa
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-04-01
Series:Frontiers in Aging Neuroscience
Subjects:
down syndrome
cilostazol
Ts65Dn mouse
behavior
inhibitor of phosphodiesterase 3
Online Access:https://www.frontiersin.org/article/10.3389/fnagi.2020.00106/full

Internet

https://www.frontiersin.org/article/10.3389/fnagi.2020.00106/full

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