Early-stage culprit in protein misfolding diseases investigated using electrochemical parameters: New insights over peptide-membrane interactions

Early-stage culprit in protein misfolding diseases investigated using electrochemical parameters: New insights over peptide-membrane interactions

The dysfunctioning of β-cells caused by the unspecific misfolding of the human islet amyloid polypeptide (hIAPP) at the membrane results in type 2 diabetes mellitus. Here, we report for the first time, the early-stage interaction of hIAPP oligomers on the DMPC (1,2-dimyristoyl-sn-glycero-3-phosphoch...

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Bibliographic Details
Main Authors: M.B. Divakara, R. Ashwini, M.S. Santosh, M. Priyanka, C.R. Ravikumar, R. Viswanatha, H.C. Ananda Murthy
Format: Article
Language:English
Published: Elsevier 2021-10-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Human islet amyloid polypeptide
Diabetes mellitus
Protein misfolding
Peptide-membrane interactions
Electrochemical technique
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332221007460

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http://www.sciencedirect.com/science/article/pii/S0753332221007460

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