Synthesis and Protective Effect of New Ligustrazine-Benzoic Acid Derivatives against CoCl2-Induced Neurotoxicity in Differentiated PC12 Cells

Synthesis and Protective Effect of New Ligustrazine-Benzoic Acid Derivatives against CoCl2-Induced Neurotoxicity in Differentiated PC12 Cells

A series of novel ligustrazine-benzoic acid derivatives were synthesized and evaluated for their protective effect against cobalt chloride-induced neurotoxicity in differentiated PC12 cells. Combining hematoxylin and eosin staining, we found compound that (3,5,6-trimethylpyrazin-2-yl)methyl 3-methox...

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Bibliographic Details
Main Authors: Haimin Lei, Lin Wang, Yuzhong Zhang, Qiang Li, Yatao Cheng, Guoliang Li, Chunxiao Chen, Jinxuan Lin, Fuhao Chu, Xin Xu, Penglong Wang, Honggui Zhang
Format: Article
Language:English
Published: MDPI AG 2013-10-01
Series:Molecules
Subjects:
ligustrazine
neuroprotective effect
cobalt chloride
PC12 cell
HE staining
Online Access:http://www.mdpi.com/1420-3049/18/10/13027

Internet

http://www.mdpi.com/1420-3049/18/10/13027

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