Stereoselective synthesis of diazaspiro[5.5]undecane derivatives via base promoted [5+1] double Michael addition of N,N-dimethylbarbituric acid to diaryliedene acetones

Stereoselective synthesis of diazaspiro[5.5]undecane derivatives via base promoted [5+1] double Michael addition of N,N-dimethylbarbituric acid to diaryliedene acetones

The nitrogen containing spiro-heterocycle is one of the privileged synthetic motif that constitutes various naturally occurring molecules and displays a broad range of pharmaceutical and biological activities. A new methodology was developed for the synthesis of 2,4-diazaspiro[5.5]undecane-1,3,5,9-t...

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Bibliographic Details
Main Authors: Mohammad Shahidul Islam, Assem Barakat, Abdullah Mohammed Al-Majid, Hazem A Ghabbour, Hoong-Kun Fun, M. Rafiq Siddiqui
Format: Article
Language:English
Published: Elsevier 2017-01-01
Series:Arabian Journal of Chemistry
Subjects:
Cascade [5+1] cycloaddition
Double Michael reaction
Diethylamine catalysis
Diazaspiro[5.5]undecane
N,N-Dimethylbarbituric acid diaryliedene acetone
Online Access:http://www.sciencedirect.com/science/article/pii/S1878535215000763

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http://www.sciencedirect.com/science/article/pii/S1878535215000763

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