JAK-STAT Pathway Inhibition Partially Restores Intestinal Homeostasis in <i>Hdac1</i>- and <i>Hdac2</i>-Intestinal Epithelial Cell-Deficient Mice

JAK-STAT Pathway Inhibition Partially Restores Intestinal Homeostasis in <i>Hdac1</i>- and <i>Hdac2</i>-Intestinal Epithelial Cell-Deficient Mice

We have previously reported that histone deacetylase epigenetic regulator <i>Hdac1</i> and <i>Hdac2</i> deletion in intestinal epithelial cells (IEC) disrupts mucosal tissue architecture and barrier, causing chronic inflammation. In this study, proteome and transcriptome anal...

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Bibliographic Details
Main Authors: Alexis Gonneaud, Naomie Turgeon, Francois-Michel Boisvert, Francois Boudreau, Claude Asselin
Format: Article
Language:English
Published: MDPI AG 2021-01-01
Series:Cells
Subjects:
intestinal epithelial cell
HDAC
proteome
transcriptome
organoid
STAT3
Online Access:https://www.mdpi.com/2073-4409/10/2/224

Internet

https://www.mdpi.com/2073-4409/10/2/224

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