Farnesoid X receptor (FXR) activation and FXR genetic variation in inflammatory bowel disease.

Farnesoid X receptor (FXR) activation and FXR genetic variation in inflammatory bowel disease.

BACKGROUND: We previously showed that activation of the bile salt nuclear receptor Farnesoid X Receptor (FXR) protects against intestinal inflammation in mice. Reciprocally, these inflammatory mediators may decrease FXR activation. We investigated whether FXR activation is repressed in the ileum and...

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Bibliographic Details
Main Authors: Rian M Nijmeijer, Raffaella M Gadaleta, Saskia W C van Mil, Adriaan A van Bodegraven, J Bart A Crusius, Gerard Dijkstra, Daan W Hommes, Dirk J de Jong, Pieter C F Stokkers, Hein W Verspaget, Rinse K Weersma, C Janneke van der Woude, Janneke M Stapelbroek, Marguerite E I Schipper, Cisca Wijmenga, Karel J van Erpecum, Bas Oldenburg, Dutch Initiative on Crohn, Colitis (ICC)
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3161760?pdf=render

Internet

http://europepmc.org/articles/PMC3161760?pdf=render

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