Fiber Derived Microbial Metabolites Prevent Acute Kidney Injury Through G-Protein Coupled Receptors and HDAC Inhibition

Fiber Derived Microbial Metabolites Prevent Acute Kidney Injury Through G-Protein Coupled Receptors and HDAC Inhibition

Short-chain fatty acids (SCFA) derived from gut microbial fermentation of fiber have been shown to exert anti-inflammatory and immune-modulatory properties in acute kidney injury (AKI). However the direct mechanistic link between SCFAs, diet and the gut microbiome is yet to be established. Using the...

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Bibliographic Details
Main Authors: Yunzi Liu, Yan J. Li, Yik W. Loh, Julian Singer, Weiping Zhu, Laurence Macia, Charles R. Mackay, Weiming Wang, Steven J. Chadban, Huiling Wu
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
gut microbiota
acute kidney injury
dietary fiber
prebiotic
SCFA
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.648639/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2021.648639/full

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