The transformation suppressor gene Reck is required for postaxial patterning in mouse forelimbs

The transformation suppressor gene Reck is required for postaxial patterning in mouse forelimbs

Summary The membrane-anchored metalloproteinase-regulator RECK has been characterized as a tumor suppressor. Here we report that mice with reduced Reck-expression show limb abnormalities including right-dominant, forelimb-specific defects in postaxial skeletal elements. The forelimb buds of low-Reck...

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Bibliographic Details
Main Authors: Mako Yamamoto, Tomoko Matsuzaki, Rei Takahashi, Eijiro Adachi, Yasuhiro Maeda, Sachiyo Yamaguchi, Hitoshi Kitayama, Michiko Echizenya, Yoko Morioka, David B. Alexander, Takeshi Yagi, Shigeyoshi Itohara, Takashi Nakamura, Haruhiko Akiyama, Makoto Noda
Format: Article
Language:English
Published: The Company of Biologists 2012-03-01
Series:Biology Open
Subjects:
Mouse
Reck
Wnt7a
Limb patterning
Cutaneous horn
Teratogens
Online Access:http://bio.biologists.org/content/1/5/458

Internet

http://bio.biologists.org/content/1/5/458

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