The interferon-gamma pathway is selectively up-regulated in the liver of patients with secondary hemophagocytic lymphohistiocytosis.

The interferon-gamma pathway is selectively up-regulated in the liver of patients with secondary hemophagocytic lymphohistiocytosis.

Aim of this study was to investigate the activation of the IFNγ pathway in the affected liver and in the blood of patients with secondary hemophagocytic lymphohistiocytosis (sHLH). To this purpose, the mRNA expression levels of IFNG and IFNγ-inducible genes as well as Tyrosine (701)-phosphorylated s...

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Main Authors: Giusi Prencipe, Claudia Bracaglia, Ivan Caiello, Antonia Pascarella, Paola Francalanci, Manuela Pardeo, Alessandra Meneghel, Giorgia Martini, Marianna N Rossi, Antonella Insalaco, Giulia Marucci, Valerio Nobili, Marco Spada, Francesco Zulian, Fabrizio De Benedetti
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0226043

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https://doi.org/10.1371/journal.pone.0226043

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