The Antidepressant Agomelatine Improves Memory Deterioration and Upregulates CREB and BDNF Gene Expression Levels in Unpredictable Chronic Mild Stress (UCMS)-Exposed Mice

The Antidepressant Agomelatine Improves Memory Deterioration and Upregulates CREB and BDNF Gene Expression Levels in Unpredictable Chronic Mild Stress (UCMS)-Exposed Mice

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Agomelatine, a novel antidepressant with established clinical efficacy, acts as an agonist of melatonergic MT 1 and MT 2 receptors and as an antagonist of 5-HT 2C receptors. The present study was undertaken to investigate whether chronic treatment with agomelatine would block unpredictable chronic m...

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Bibliographic Details
Main Authors: Esen Gumuslu, Oguz Mutlu, Deniz Sunnetci, Guner Ulak, Ipek K. Celikyurt, Naci Cine, Furuzan Akar, Hakan Savli, Faruk Erden
Format: Article
Language:English
Published: AboutScience Srl 2014-01-01
Series:Drug Target Insights
Online Access:https://doi.org/10.4137/DTI.S13870

Internet

https://doi.org/10.4137/DTI.S13870

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