Lack of the E3 Ubiquitin Ligase March1 Affects CD8 T Cell Fate and Exacerbates Insulin Resistance in Obese Mice

Lack of the E3 Ubiquitin Ligase March1 Affects CD8 T Cell Fate and Exacerbates Insulin Resistance in Obese Mice

Obesity is a major risk factor for the development of insulin resistance and type 2 diabetes. However, the mechanisms that trigger the underlying adipose tissues inflammation are not completely understood. Here, we show that the E3 ubiquitin ligase March1 controls the phenotypic and functional prope...

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Bibliographic Details
Main Authors: Abdelilah Majdoubi, Jun Seong Lee, Osama A. Kishta, Mohammad Balood, Mohamed Abdelwafi Moulefera, Satoshi Ishido, Sébastien Talbot, Cheolho Cheong, Thierry Alquier, Jacques Thibodeau
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-08-01
Series:Frontiers in Immunology
Subjects:
March1
obesity
T cell metabolism
memory CD8 T cell
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.01953/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.01953/full

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